♥ Book Title : Chemistry and Biology of N-Nitroso Compounds
☯ Full Synopsis : "Originally published in 1992, this volume looks in depth at the carcinogenic properties of N-nitroso compounds. These compounds occur widely in smoked foods and in meat and fish cured with nitrates; they are also formed in some industrial processes and in addition are found in cosmetics, tobacco and tobacco smoke. By focusing on the chemical and biological properties, the volume attempts to explain how these compounds exert their carcinogenic potential and, furthermore, goes on to explain how apparently harmless precursors such as nitrates and amines are transformed to produce carcinogens."Article| William Lijinsky| Statement ..."
✩ Chemistry And Biology Of N Nitroso Compounds ✩
Top results of your surfing
✪ Chemistry And Biology Of N Nitroso Compounds ✪ Start Download Portable Document Format (PDF) and E-books (Electronic Books) Free Online Rating News 2016/2017 is books that can provide inspiration, insight, knowledge to the reader.
♥ Book Title : Nitrosamines and Related N-nitroso Compounds
☯ Full Synopsis : "Presents recent advances in prevention of nitrosamine formation in vitro and in vivo. Discusses mechanisms of N-nitroso compound formation and denitrosation. Reviews the metabolism of nitrosamines and the modification of DNA and proteins by the products of metabolism. Examines the effects of dietary components and other chemopreventive agents on N-nitroso compound metabolism and carcinogenicity. Discusses the use of specific biomarkers of nitrosamine exposure in humans and in animal models and covers their role in the molecular epidemiology of tobacco-derived nitrosamines."Article| Richard N. Loeppky| Statement ..."
♥ Book Title : Nitrosation Reactions and the Chemistry of Nitric Oxide
☯ Full Synopsis : "Since 1988, there has been much literature published on the chemistry of nitric oxide, particularly in the field of S-nitrosation and the chemistry of S-nitroso compounds. Written by a chemist for the chemistry community, this book provides an update of the chemistry of nitrosation reactions, dealing with both the synthetic and mechanistic aspects of these reactions. It also looks at the chemistry of nitric oxide in relation to the amazing biological properties of this simple diatomic molecule, which were unknown until around 1990. * Provides an update on previously published literature on nitric oxide chemistry * Contains chapters on reagents for nitrosation, nitrosation at nitrogen, aliphatic and aromatic carbon, oxygen, sulfur and metal centres * Looks at hot research topics such as synthesis, properties and reactions of s-nitrosothiols"Article| D.L.H. Williams| Statement ..."
♥ Book Title : Introduction to Bioorganic Chemistry and Chemical Biology
☯ Full Synopsis : "Introduction to Bioorganic Chemistry and Chemical Biology is the first textbook to blend modern tools of organic chemistry with concepts of biology, physiology, and medicine. With a focus on human cell biology and a problems-driven approach, the text explains the combinatorial architecture of biooligomers (genes, DNA, RNA, proteins, glycans, lipids, and terpenes) as the molecular engine for life. Accentuated by rich illustrations and mechanistic arrow pushing, organic chemistry is used to illuminate the central dogma of molecular biology. Introduction to Bioorganic Chemistry and Chemical Biology is appropriate for advanced undergraduate and graduate students in chemistry and molecular biology, as well as those going into medicine and pharmaceutical science."Article| David Van Vranken| Statement ..."
♥ Book Title : Chemical Carcinogenesis
☯ Full Synopsis : "About two centuries after the communication by Sir Percival Pott that the "chimney sweeper disease" was a cancer and its suggestion that active compounds of soot were the causative agents, and about one century after the description of urinary bladder cancer in dye workers, an enormous number of substances have been synthesized and have probably come into contact with man. Research in cancer prevention is of primary importance, and may receive continuous support from new discoveries on cancer etiology and pathogenesis. If one accepts the multistage model of chemical carcinogenesis, one has also to accept that many events occur between the contact of carcino genic compounds and their specific targets and the development of a clinically recognizable neoplasm. Thus, animal studies become essential to elucidate the different steps by which chemical carcinogens induce neoplasia. The analysis of these steps and the comparative evaluation of experimental models is essential to an understanding of pathogenesis."Article| Francisco Feo| Statement ..."
♥ Book Title : The Chemical Components of Tobacco and Tobacco Smoke
☯ Full Synopsis : "The Chemical Components of Tobacco and Tobacco Smoke chronicles the extraordinary progress made by scientists in the field of tobacco science, from its beginnings in the early 1800s to the present. This comprehensive text provides over 6000 references on more than 8400 components identified in tobacco and tobacco smoke.Authored by two longtime rese"Article| Alan Rodgman| Statement ..."
♥ Book Title : Genotoxicology of N-Nitroso Compounds
☯ Full Synopsis : "Toph's in Chemical Mutagenesis is a new series dedicated to studies in the areas of environmental chemical mutagenesis and genetic toxicology. In this series we will explore some of many topics that are emerging in these rapidly developing fields. The purpose of the present volume is to attempt to organize and compare the genotoxic properties of the N-nitroso compounds. This is a particularly interesting class of compounds because of the problems encountered with the Salmonella assay of Ames in generating both false positive and false negative results. The battery approach using a number of assay systems seems more appropriate to evaluate chemicals in this class. Topics to be discussed in other volumes in this series include single-cell mutation monitoring systems, the detection of genetic damage in mammalian germ cells, the mutagenicity of pesticides, problems in monitoring human populations in genetic toxicology, and a glossary of terms in genetic toxicology. All of these books are in various stages of development and should appear within the next few years. Frederick J. de Serres Series Editor vii Preface During the past ten years there has been an explosive development in the number of short-term tests to predict the biological risks, especially risks of cancer, in exposure to xenobiotic chemicals. The number of published articles in this area has reached many thousands a year and there are several new journals devoted almost entirely to the presentation of the results obtained in these tests."Article| T. Rao| Statement ..."
♥ Book Title : Cancer Risk Assessment
☯ Full Synopsis : "With a weight-of-the-evidence approach, cancer risk assessment indentifies hazards, determines dose-response relationships, and assesses exposure to characterize the true risk. This book focuses on the quantitative methods for conducting chemical cancer risk assessments for solvents, metals, mixtures, and nanoparticles. It links these to the basic toxicology and biology of cancer, along with the impacts on regulatory guidelines and standards. By providing insightful perspective, Cancer Risk Assessment helps researchers develop a discriminate eye when it comes to interpreting data accurately and separating relevant information from erroneous."Article| Ching-Hung Hsu| Statement ..."
♥ Book Title : N-Nitroso Compounds
☯ Full Synopsis : ""Article| no defined| Statement ..."
♥ Book Title : Aging, Carcinogenesis, and Radiation Biology
☯ Full Synopsis : "The covalent attachment to deoxyribonucleic acid in vivo of a large number of different types of chemical compounds (both normal cellular constituents such as proteins and amino acids, and also exogenous compounds such as drugs, carcinogens, etc. ) have been shown to exert profound effects upon cells. Four research activi ties, formerly considered to be totally independent, relate to this problem of nucleic acid adducts--(1) normal covalent attachment of DNA to membranes, protein linkers in chromosomes, etc. ; (2) the roles of radiation and chemical enhancement of DNA adduct formation in cell killing and mutagenesis. (A related field is the use of known cross-linking reactions to gain information on structural associations in macromolecular complexes. ); (3) the relevance of DNA adducts to chemical and radiation carcinogenesis; (4) the rele vance of DNA adducts to the cross-linking theory of cellular aging. (1) There are numerous examples of normal linkages between DNA and protein, e. g. , DNA-membrane attachment sites, protein linkers in chromosomes, amino acids covalently linked to DNA as a function of growth conditions, and gene regulation by non-covalently bound proteins. A summary of data on natural adducts to DNA thus serves to introduce the subject of the radiation and chemical enhancement of DNA adduct formation. (2) In the past, radiation biology has been concerned mainly with trying to understand the radiation chemistry of purified DNA, and the biological effects and repair of these radiation-induced alterations when produced in cellular DNA."Article| Kendric Smith| Statement ..."
♥ Book Title : N-nitroso Compounds
☯ Full Synopsis : ""Article| International Agency for Research on Cancer| Statement ..."
♥ Book Title : Aromatic C-nitroso Compounds
☯ Full Synopsis : "This book is designed to collect and review the research covering main directions in investigations of aromatic nitroso compounds in last decades, and to present both, the academic aspects of this chemistry, as well as the open field of its applicability. The book is divided in five chapters. The basic structural properties of the nitroso aromatic molecules are described in the first chapter. The second chapter is an overview of the methods of preparations of aromatic nitroso and polynitroso compounds, including classical synthetic methods and some new preparative approaches. The third part deals with the physico-chemical properties of nitroso aromates and azodioxides, its structure, crystallography, quantum chemical calculations, spectroscopy, typical reactions, and especially it is focused on the dimerizations in the solid-state. In the fourth chapter is represented organometallic chemistry of nitroso aromatic molecules and its applications in catalysis. The last part of the book deals with the behavior of this class of compounds in the biological systems, reactions with biomolecules and the use in toxicology."Article| Hrvoj Vančik| Statement ..."